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apalutamide will decrease the level or impact of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with medication which can be CYP3A4 substrates may end up in lessen exposure to those medicines.To look at formulary data to start with